This sounds like quite the charming big-screen duo. Zach Galifianakis from "The Hangover" and Amy Adams are in talks to join John Carney's upcoming Fox 2000 comedy-drama "Town House."

The story, according to Variety, follows an agoraphobic man who lives in a Boston townhouse and befriends a call girl after he sees the royalties from the work of his rock star father dimish rather quickly.

Doug Wright and Carney wrote the screenplay, which is inspired by Tish Cohen's novel. Brothers Ridley and Tony Scott are on board to produced the project, which fell victim to the recent writers strike.

Adams recently starred in "Night at the Museum: Battle of the Smithsonian." She will soon be seen in "The Fighter" and "Leap Year."

As for Galifianakis, the success of "The Hangover" boosted his career, and he's got many projects lined up. "Dinner for Schmucks," "Due Date" and "It's Kind of a Funny Story" are on his radar.