Bradley Cooper and Ed Helms are in talks to star in Todd Phillips’ upcoming comedy “The Hangover,” according to The Hollywood Reporter.

The film centers on three best friends who literally lose the groom during his wild bachelor party in Las Vegas.

Phillips is directing a script by Jon Lucas and Scott Moore, who also wrote Christian Charles’ “Full of It” and Mark Waters’ upcoming romantic comedy “The Ghosts of Girlfriends Past.”

Cooper will next be seen in Ken Kwapis’ comedy “He’s Just Not That Into You.” He also recently wrapped filming for Peyton Reed’s comedy “Yes Man,” which stars Jim Carrey and Zooey Deschanel.

Helms can currently be seen in “Meet Dave.” He’s also filming “Night at the Museum 2: Battle of the Smithsonian.”

As for Phillips, he most recently directed “School for Scoundrels.”