Rhys Ifans, Chloë Sevigny and David Thewlis are in talks to star in Bernard Rose’s adaptation of Howard Marks’ autobiography “Mr. Nice.”

According to the Hollywood Reporter, the plot focuses on an Oxford graduate and teacher (Ifans) who becomes a drug smuggler to impress his wife (Sevigny) but quickly ends up on Britain’s list of most-wanted criminals.

While seeking help from an Irish Republican Army boss (Thewlis), a British spy offers him a job as informant.

Ifans, who recently starred in “Elizabeth: The Golden Age,” will next be seen in Gregor Jordan’s “The Informers,” followed by Jaco van Dormael’s “Mr. Nobody.”

Sevigny’s big-screen credits include “Melinda and Melinda,” “Broken Flowers” and “Zodiac.” She’s also known for her role as Nicolette Grant on TV’s ”Big Love.”

As for Thewlis, he’ll return as Remus Lupin in David Yates’ “Harry Potter and the Half-Blood Prince.”